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76 Other recent analyses have revealed survodutide, tirzepatide, and retatrutide to each significantly reduce liver fat with no evidence of worsening in markers of liver fibrosis.77, 78, 79 Depression and suicidality Most studies evaluating depression and GLP-1 RA use were conducted in those with T2DM and indicate no increased risk

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However, this could not be confirmed using the CIS20r concentration scale

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